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Article

Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death.

Basic research in cardiology - 1 Sept 2010

Hirschy Alain, Croquelois Adrien, Perriard Evelyne, Schoenauer Roman, Agarkova Irina, Hoerstrup Simon P, Taketo Makoto M, Pedrazzini Thierry, Perriard Jean-Claude, Ehler Elisabeth

Abstract excerpt

Beta-catenin is a component of the intercalated disc in cardiomyocytes, but can also be involved in signalling and activation of gene transcription. We wanted to determine how long-term changes in beta-catenin expression levels would affect mature cardiomyocytes. Conditional transgenic mice that either lacked beta-catenin or that expressed a non-degradable form of beta-catenin in the adult ventricle were created....

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Source

Identifiers

PMID: 20376467
DOI: 10.1007/s00395-010-0101-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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