The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII.

Article

The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII.

The Journal of biological chemistry - 5 Jun 1991

Rehemtulla A, Ruf W, Edgington T S

Abstract excerpt

The structural basis of function of tissue factor (TF), the cell surface receptor and cofactor for the serine protease factor VIIa, cannot be inferred from the primary sequence. The functional significance of the two disulfide bonded loops in the surface domain of TF has been analyzed using site-...

Topics

Animals
Base Sequence
Blotting, Western
Cell Line
Cricetinae
Cricetulus
Cysteine
Disulfides
Factor VII
Flow Cytometry
Molecular Sequence Data
Mutation
Thromboplastin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.