Article
Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene.
The Journal of biological chemistry - 5 Jun 1991
Kariya K, Karns L R, Simpson P C
Abstract excerpt
Cultured neonatal rat cardiac myocytes express at least three isozymes of protein kinase C (PKC), and two PKC isozymes are translocated to different intracellular sites on activation with alpha 1-adrenergic agonists or phorbol myristate acetate. Differential intracellular localization upon activa...
Topics
- Animals
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Gene Expression Regulation, Enzymologic
- Isoenzymes
- Mutation
- Myocardium
- Myosins
- Plasmids
- Promoter Regions, Genetic
- Protein Kinase C
- Rats
- Transcription, Genetic
- Transfection