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Article

Deficiency of the alpha-subunit of the stimulatory G protein and severe extraskeletal ossification.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2000

Eddy M C, Jan De Beur S M, Yandow S M, McAlister W H, Shore E M, Kaplan F S, Whyte M P, Levine M A

Abstract excerpt

Progressive osseous heteroplasia (POH) is a rare disorder characterized by dermal ossification beginning in infancy followed by increasing and extensive bone formation in deep muscle and fascia. We describe two unrelated girls with typical clinical, radiographic, and histological features of POH who also have findings of another uncommon heritable disorder, Albright hereditary osteodystrophy (AHO). One patient...

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Share to Fibrous Dysplasia, Polyostotic
Share to GTP-Binding Protein alpha Subunits, Gs

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hand Deformities, Congenital

Share to Ossification, Heterotopic

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Source

Identifiers

PMID: 11092390
DOI: 10.1359/jbmr.2000.15.11.2074

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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