Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diseases associated with mutations of the human lutropin receptor.

Progress in molecular biology and translational science - 1 Jan 2009

Segaloff Deborah L

Abstract excerpt

The human lutropin receptor (LHCGR) plays an integral role in male and female reproductive physiology. In response to either placental hCG or pituitary LH, gonadal LHCGR mediates its effects primarily through Gs activation. Heterozygous mutations leading to constitutive activation of the LHCGR cause gonadotropin-independent precocious puberty in males, but have no detectable effects on prepubertal or postpubertal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to LHCGR gene
Share to Disease
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Receptors, LH

Source

Identifiers

PMID: 20374734
DOI: 10.1016/S1877-1173(09)89004-2

Genes

LHCGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diseases associated with mutations of the human lutropin receptor.PMID 20374734Read ↗

Inactivating mutations of the human luteinizing hormone receptor in both sexes.Semantic proximity Read ↗

Naturally occurring mutations of the luteinizing hormone receptor gene affecting reproduction.Semantic proximity Read ↗

Male pseudohermaphroditism due to inactivating luteinizing hormone receptor mutations.Semantic proximity Read ↗

Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Semantic proximity Read ↗

Luteinizing hormone receptor mutations in disorders of sexual development and cancer.Semantic proximity Read ↗

Activating and inactivating mutations in LH receptors.Semantic proximity Read ↗

Activating mutations of the lutropin choriogonadotropin receptor in precocious puberty.Semantic proximity Read ↗

Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations.Semantic proximity Read ↗

G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease.Semantic proximity Read ↗

Mutations affecting gonadotropin secretion and action.Semantic proximity Read ↗

Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women.Semantic proximity Read ↗

[Inactivating and activating mutations of the human LH/hCG receptor leading to male pseudohermaphroditism and familial male-limited precocious puberty].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.