Article
PAI-1 4G/5G polymorphism is associated with brain vessel reocclusion after successful fibrinolytic therapy in ischemic stroke patients.
The International journal of neuroscience - 1 Apr 2010
Fernandez-Cadenas I, Del Rio-Espinola A, Rubiera M, Mendioroz M, Domingues-Montanari S, Cuadrado E, Hernandez-Guillamon M, Rosell A, Ribo M, Alvarez-Sabin J, Molina C A, Montaner J
Abstract excerpt
BACKGROUND: Despite t-PA proven benefits related to vessel reopening, up to 13% of stroke patients suffer reocclusions after t-PA. We aimed to analyze whether a functional polymorphism in a fibrinolysis inhibitor gene [plasminogen activator inhibitor-1 (PAI-1)] might be associated with reocclusion rates after stroke thrombolytic therapy. METHODS: 165 patients with ischemic stroke who received t-PA < 3 h were...
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