Article
Antigenic epitopes in the hemagglutinin of Qinghai-type influenza H5N1 virus.
Viral immunology - 1 Apr 2010
Rudneva Irina A, Kushch Alla A, Masalova Olga V, Timofeeva Tatiana A, Klimova Regina R, Shilov Aleksandr A, Ignatieva Anna V, Krylov Petr S, Kaverin Nikolai V
Abstract excerpt
The highly pathogenic avian influenza H5N1 viruses have become widespread and evolved into several clades. In our previous studies, the antigenic sites of the H5 hemagglutinin (HA) were characterized by selection and sequencing of escape mutants. In the present studies we analyzed the antigenic epitopes recognized by monoclonal antibodies against avian influenza A/Duck/Novosibirsk/56/05 (H5N1) virus isolated in...
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