Article
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Mar 2010
Hishida Asahi, Matsuo Keitaro, Goto Yasuyuki, Mitsuda Yoko, Hiraki Akio, Naito Mariko, Wakai Kenji, Tajima Kazuo, Hamajima Nobuyuki
Abstract excerpt
BACKGROUND: The aberrant expression of activation-induced cytidine deaminase (AICDA) was reportedly induced in gastric epithelial cells infected with cytotoxin-associated gene A (cagA)-positive Helicobacter pylori, resulting in the accumulation of alterations in the TP53 tumor suppressor gene in gastric cells. We investigated the association of the AICDA 7888 C/T polymorphism with H. pylori infection and the risk...
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