Article
Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.
Journal of clinical gastroenterology - 1 Apr 2008
Sawaya Manabu, Yoshimura Tetsuro, Shimoyama Tadashi, Munakata Akihiro, Fukuda Shinsaku
Abstract excerpt
GOALS: To examine the significance of alteration of p53-regulated apoptosis-induced protein 1 (p53AIP1) expression in gastric carcinogenesis in patients with Helicobacter pylori infection. BACKGROUND: H. pylori infection induces gastric mucosal inflammation and DNA damage of epithelial cells, which associate with gastric carcinogenesis. p53AIP1 is expressed after DNA damage and induces apoptosis in human cell...
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