Article
Genetic factors involved in the development of Helicobacter pylori-related gastric cancer.
Cancer science - 1 Nov 2006
Hamajima Nobuyuki, Naito Mariko, Kondo Takaaki, Goto Yasuyuki
Abstract excerpt
Developmental process to gastric cancer by Helicobacter pylori infection consists of three steps: (1) H. pylori infection; (2) gastric atrophy development; and (3) carcinogenesis. In each step, genetic traits may influence the process, interacting with lifestyle. In the step of H. pylori infection, two lines of genetic polymorphisms were assumed: one influencing gastric acid inhibition interacting with smoking,...
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