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Article

Alpha-hemoglobin stabilizing protein (AHSP), a kinetic scheme of the action of a human mutant, AHSPV56G.

The Journal of biological chemistry - 4 Jun 2010

Brillet Thomas, Baudin-Creuza Véronique, Vasseur Corinne, Domingues-Hamdi Elisa, Kiger Laurent, Wajcman Henri, Pissard Serge, Marden Michael C

Abstract excerpt

A kinetic analysis has been made of the interaction of alpha-Hb chains with a mutant alpha-hemoglobin stabilizing protein, AHSP(V56G), which is the first case of an AHSP mutation associated with clinical symptoms of mild thalassemia syndrome. The chaperone AHSP is thought to protect nascent alpha chains until final binding to the partner beta-Hb. Rather than protecting alpha chains, the mutant chaperone is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20371604
DOI: 10.1074/jbc.M109.098491
PMCID: PMC2878560

Genes

AHSP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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