Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes

1 Apr 2010

Abstract excerpt

Cryptococcus neoformans is a haploid environmental organism and the major cause of fungal meningoencephalitis in AIDS patients. Fluconazole (FLC), a triazole, is widely used for the maintenance therapy of cryptococcosis. Heteroresistance to FLC, an adaptive mode of azole resistance, was associated with FLC therapy failure cases but the mechanism underlying the resistance was unknown. We used comparative genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Infections and Studies
Share to Plant Disease Resistance and Genetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20368972
DOI: 10.1371/journal.ppat.1000848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple ChromosomesPMID 20368972Read ↗

Aneuploidy underlies brefeldin A-induced antifungal drug resistance in Cryptococcus neoformansSemantic proximity Read ↗

Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida aurisSemantic proximity Read ↗

Aneuploidy Formation in the Filamentous Fungus Aspergillus flavus in Response to Azole StressSemantic proximity Read ↗

Hotspot mutations and genomic expansion of ERG11 are major mechanisms of azole resistance in environmental and human commensal isolates of Candida tropicalis.Semantic proximity Read ↗

The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogenSemantic proximity Read ↗

Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosisSemantic proximity Read ↗

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.Semantic proximity Read ↗

Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype ASemantic proximity Read ↗

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs.Semantic proximity Read ↗

Microevolution of Cryptococcus neoformans Driven by Massive Tandem Gene AmplificationSemantic proximity Read ↗

Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitisSemantic proximity Read ↗

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.