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Article

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010

Wang Lifeng, Jin Qihuang, Lee Ji-Eun, Su I-hsin, Ge Kai

Abstract excerpt

Wnt/beta-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the role of Ezh2 in adipogenesis, remain unclear. Here we show Ezh2 and its H3K27 methyltransferase activity are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20368440
DOI: 10.1073/pnas.1000031107
PMCID: PMC2867706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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