Article
Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Feb 2010
Wang Li-Hsuan, Ting Shuo-Chun, Chen Chung-Ho, Tsai Chi-Cheng, Lung Oliver, Liu Ta-Chih, Lee Chia-Wen, Wang Yen-Yun, Tsai Chin-Ling, Lin Ying-Chu
Abstract excerpt
BACKGROUND: Our aim was to measure the relationship of FAS (-1377G>A and -670A>G), FASL (-844C>T) gene variants and risk of oral cancer. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to determine the FAS and FASL polymorphisms in 294 oral squamous cell carcinoma (OSCC), 53 oral submucous fibrosis (OSF), and 84 oral leukoplakia (OL) patients, as well as in...
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