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Article

Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

31 Mar 2010

Abstract excerpt

The central event in protein misfolding disorders (PMDs) is the accumulation of a misfolded form of a naturally expressed protein. Despite the diversity of clinical symptoms associated with different PMDs, many similarities in their mechanism suggest that distinct pathologies may cross talk at the molecular level. The main goal of this study was to analyze the interaction of the protein misfolding processes...

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PMID: 20357103
DOI: 10.1523/jneurosci.5924-09.2010

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