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Article

Conditional cell-wall mutants of Saccharomyces cerevisiae as delivery vehicles for therapeutic agents in vivo to the GI tract.

Journal of biotechnology - 17 May 2010

Omara Walid A M, Rash Bharat M, Hayes Andrew, Wickham Martin S J, Oliver Stephen G, Stateva Lubomira I

Abstract excerpt

Strains of Saccharomyces cerevisiae capable of lysis upon conditional down-regulation of cell-wall biogenesis genes (SRB1 and PKC1) have been reported. Here, we show that they lyse and release recombinant protein not only under laboratory conditions, but (more importantly) under conditions found in the human stomach and duodenum. These findings provide proof that, in principle, such conditional lysis strains...

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Identifiers

PMID: 20356564
DOI: 10.1016/j.jbiotec.2010.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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