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Article

Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements.

BMC cancer - 31 Mar 2010

Sanders Anne M, Stehle John R, Blanks Michael J, Riedlinger Gregory, Kim-Shapiro Jung W, Monjazeb Arta M, Adams Jonathan M, Willingham Mark C, Cui Zheng

Abstract excerpt

BACKGROUND: Spontaneous Regression/Complete Resistant (SR/CR) mice are a colony of cancer-resistant mice that can detect and rapidly destroy malignant cells with innate cellular immunity, predominately mediated by granulocytes. Our previous studies suggest that several effector mechanisms, such as perforin, granzymes, or complements, may be involved in the killing of cancer cells. However, none of these effector...

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Identifiers

PMID: 20356394
DOI: 10.1186/1471-2407-10-121
PMCID: PMC2861034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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