Article
Transferable anticancer innate immunity in spontaneous regression/complete resistance mice.
Proceedings of the National Academy of Sciences of the United States of America - 16 May 2006
Hicks Amy M, Riedlinger Gregory, Willingham Mark C, Alexander-Miller Martha A, Von Kap-Herr C, Pettenati Mark J, Sanders Anne M, Weir Holly M, Du Wei, Kim Joseph, Simpson Andrew J G, Old Lloyd J, Cui Zheng
Abstract excerpt
Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rosettes with infiltrating natural killer cells, neutrophils, and macrophages was required for the...
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