Article
A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion.
The pharmacogenomics journal - 1 Jun 2011
Kim I, Kang E S, Yim Y S, Ko S J, Jeong S-H, Rim J H, Kim Y S, Ahn C W, Cha B S, Lee H C, Kim C H
Abstract excerpt
SLC30A8 encodes the β-cell-specific zinc transporter-8 (ZnT-8) expressed in insulin secretory granules. The single-nucleotide polymorphism rs13266634 of SLC30A8 is associated with susceptibility to post-transplantation diabetes mellitus (PTDM). We tested the hypothesis that the polymorphic residue at position 325 of ZnT-8 determines the susceptibility to cyclosporin A (CsA) suppression of insulin secretion. INS...
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