Article
A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.
Diabetes - 1 Apr 2008
Kang Eun Seok, Kim Myoung Soo, Kim Yu Seun, Kim Chul Hoon, Han Seung Jin, Chun Sung Wan, Hur Kyu Yeon, Nam Chung Mo, Ahn Chul Woo, Cha Bong Soo, Kim Soon Il, Lee Hyun Chul
Abstract excerpt
OBJECTIVE: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients, and insulin secretory defects play an important role in the pathogenesis of PTDM. The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin...
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