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Article

Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.

Molecular endocrinology (Baltimore, Md.) - 1 May 2010

Bredfeldt Tiffany G, Greathouse K Leigh, Safe Stephen H, Hung Mien-Chie, Bedford Mark T, Walker Cheryl L

Abstract excerpt

Although rapid, membrane-activated estrogen receptor (ER) signaling is no longer controversial, the biological function of this nongenomic signaling is not fully characterized. We found that rapid signaling from membrane-associated ER regulates the histone methyltransferase enhancer of Zeste homolog 2 (EZH2). In response to both 17beta-estradiol (E2) and the xenoestrogen diethylstilbestrol, ER signaling via...

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Identifiers

PMID: 20351197
DOI: 10.1210/me.2009-0438
PMCID: PMC2870935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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