Article
Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2007
Cook Jennifer DeAnn, Davis Barbara J, Goewey Julia Alicia, Berry Tia D, Walker Cheryl Lyn
Abstract excerpt
Epidemiological and experimental animal studies have shown that exposure to xenoestrogens during reproductive tract development reprograms target tissues, leading to increased disease risk later in adult life. To understand what defines the critical risk period for this effect, termed developmental programming, the authors assess the sensitivity of the female reproductive tract to developmental programming during...
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