Article
High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia.
The Journal of infectious diseases - 1 May 2010
Anderson Tim J C, Nair Shalini, Nkhoma Standwell, Williams Jeff T, Imwong Mallika, Yi Poravuth, Socheat Duong, Das Debashish, Chotivanich Kesinee, Day Nicholas P J, White Nicholas J, Dondorp Arjen M
Abstract excerpt
In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. We measured heritability of clearance rate by evaluating patients infected with identical or nonidentical parasite genotypes, using methods analogous to human twin studies. A substantial proportion...
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