Article
Prospective association of dopamine-related polymorphisms with smoking cessation in general care.
Pharmacogenomics - 1 Apr 2010
Breitling Lutz P, Twardella Dorothee, Hoffmann Michael M, Witt Stephanie H, Treutlein Jens, Brenner Hermann
Abstract excerpt
AIMS: Genetic contributions to nicotine dependence have been demonstrated repeatedly, but the relevance of individual polymorphisms for smoking cessation remains controversial. MATERIALS & METHODS: We examined genotypes at two dopamine-related loci, DRD2/ANKK1 (rs1800497) and DBH (rs77905), in 577 heavy smokers participating in a prospective study of smoking cessation in general care in Germany. RESULTS: Smoking...
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