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Article

Structure, dynamics and immunogenicity of a catalytically inactive C X C chemokine-degrading protease SpyCEP from Streptococcus pyogenes

1 Jan 2020

Abstract excerpt

Cell-Envelope Proteinase) is a surface-exposed serine protease that inactivates chemokines, impairing neutrophil recruitment and bacterial clearance, and has shown promising immunogenicity in preclinical models. Although SpyCEP structure has been partially characterized, a more complete and higher resolution understanding of its antigenic features would be desirable prior to large scale manufacturing. To address...

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PMID: 32257048
DOI: 10.1016/j.csbj.2020.03.004

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