Hepatic ceruloplasmin gene expression is unaltered in the toxic milk mouse.

Abstract excerpt

The toxic milk mutation in mice is an autosomal recessive condition that causes a marked hepatic accumulation of copper in the adults, but is also characterized by severe copper deficiency in the pups of toxic dams. To establish whether the mutation affects ceruloplasmin (CP) gene expression, we analyzed the steady state levels of CP mRNA in mutant and normal animals at various stages of development and following...

Topics

• Animals
• Animals, Newborn
• Ceruloplasmin
• Copper
• Female
• Fetus
• Gene Expression
• Liver
• Male
• Mice
• Mice, Inbred Strains
• Mutation
• Pregnancy