Toxic milk, a new mutation affecting cooper metabolism in the mouse.

Abstract excerpt

Toxic milk, tx, a new autosomal recessive mutation in mice is described. Litters produced by mutant females display a syndrome including poor growth, hypopigmentation, tremors, and ultimately death at two weeks of age. These features, consistent with copper deficiency, are attributed to failure in gestational hepatic copper accumulation exacerbated by subsistence on milk with greatly reduced copper content. Such...

Topics

• Animals
• Copper
• Crosses, Genetic
• Female
• Genes, Recessive
• Heterozygote
• Homozygote
• Metal Metabolism, Inborn Errors
• Mice
• Mice, Mutant Strains
• Milk
• Mutation