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Article

Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Journal of medicinal chemistry - 22 Apr 2010

Qian Keduo, Kuo Reen-Yun, Chen Chin-Ho, Huang Li, Morris-Natschke Susan L, Lee Kuo-Hsiung

Abstract excerpt

In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3' dimethyl group of bevirimat (2), the...

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Identifiers

PMID: 20329730
DOI: 10.1021/jm901782m
PMCID: PMC2860721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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