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Article

Molecular Biology of the Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Family

1 Jan 2000

Abstract excerpt

Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor family consistently associated with chromosomal translocation and functional fusion of the EWS gene to any of several structurally related transcription factor genes. Similar gene fusion events occur in other mesenchymal and hematopoietic tumors and are tumor-specific. The resulting novel transcription factor-like chimeric...

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PMID: 10623711
DOI: 10.1200/jco.2000.18.1.204

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