Article
Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.
Bone - 1 Jul 2010
Perrier A, Dumas V, Linossier M T, Fournier C, Jurdic P, Rattner A, Vico L, Guignandon A
Abstract excerpt
Bone matrix, mainly composed of type I collagen and apatite, is constantly modified during the bone remodeling process, which exposes bone cells to various proportions of mineralized collagen within bone structural units. Collagen-mineralized substrates have been shown to increase osteoblast activities. We hypothesized that such effects may be explained by a rapid secretion of specific growth factors and/or...
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