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Article

Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes.

Stem cell research - 1 May 2010

Jonsson Malin K B, Duker Göran, Tropp Charlotte, Andersson Birgit, Sartipy Peter, Vos Marc A, van Veen Toon A B

Abstract excerpt

To improve proarrhythmic predictability of preclinical models, we assessed whether human ventricular-like embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be selected following a standardized protocol. Also, we quantified their arrhythmogenic response and compared this to a contemporary used rabbit Purkinje fiber (PF) model. Multiple transmembrane action potentials (AP) were recorded from 164 hESC-CM...

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Identifiers

PMID: 20303332
DOI: 10.1016/j.scr.2010.02.001

Genes

GJA5
HCN1
KCNA5
KCNJ2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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