Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis.

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Article

Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis.

Canadian journal of microbiology - 1 Jun 2000

Cropp T A, Smogowicz A A, Hafner E W, Denoya C D, McArthur H A, Reynolds K A

Abstract excerpt

Fatty-acid biosynthesis by a branched-chain alpha-keto acid dehydrogenase (bkd) mutant of Streptomyces avermitilis was analyzed. This mutant is unable to produce the appropriate precursors of branched-chain fatty acid (BCFA) biosynthesis, but unlike the comparable Bacillus subtilis mutant, was shown not to have an obligate growth requirement for these precursors. The bkd mutant produced only straight-chain fatty...

Topics

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Anaerobiosis
Bacillus subtilis
Fatty Acids
Ivermectin
Ketone Oxidoreductases
Multienzyme Complexes
Mutation
Streptomyces
Temperature

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Open in PubMed

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PMID: 10913971

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