Article
A hypoplastic retinal lamination in the purpurin knock down embryo in zebrafish.
Advances in experimental medicine and biology - 1 Jan 2010
Nagashima Mikiko, Saito Junichi, Mawatari Kazuhiro, Mori Yusuke, Matsukawa Toru, Koriyama Yoshiki, Kato Satoru
Abstract excerpt
Recently, we cloned a photoreceptor-specific purpurin cDNA from axotomized goldfish retina. In the present study, we investigate the structure of zebrafish purpurin genomic DNA and its function during retinal development. First, we cloned a 3.7-kbp genomic DNA fragment including 1.4-kbp 5'-flanking region and 2.3-kbp full-length coding region. In the 1.4-kbp 5'-upstream region, there were some cone-rod homeobox...
Topics
- Animals
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Gene Knockdown Techniques
- Homeodomain Proteins
- Oligonucleotides, Antisense
- Organ Specificity
- Phenotype
- RNA, Messenger
- Retina
- Retinol-Binding Proteins
- Tolonium Chloride
- Trans-Activators
- Zebrafish
- Zebrafish Proteins