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Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes

1 Dec 2009

Abstract excerpt

Mutations in the human RPGR gene cause one of the most common and severe forms of inherited retinal dystrophy, but the function of its protein product remains unclear. We have identified two genes resembling human RPGR (ZFRPGR1, ZFRPGR2) in zebrafish (Danio rerio), both of which are expressed within the nascent and adult eye as well as more widely during development. ZFRPGR2 appears to be functionally orthologous...

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PMID: 19955120
DOI: 10.1093/hmg/ddp533

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