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Article

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells.

Breast cancer research and treatment - 1 Jan 2011

Shi Ming, Liu Dan, Duan Huijun, Qian Lu, Wang Lina, Niu Lijia, Zhang Huipeng, Yong Zheng, Gong Zehui, Song Lun, Yu Ming, Hu Meiru, Xia Qing, Shen Beifen, Guo Ning

Abstract excerpt

In this study, β2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/Her2). Correlation of β2-AR level with Her2 status was demonstrated in breast cancer tissue samples. Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells. β2-AR expression induced by epinephrine and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20237834
DOI: 10.1007/s10549-010-0822-2

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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