Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling

Abstract excerpt

BACKGROUND: Opioid and beta-adrenergic receptors are recently shown to cross talk via formation of receptor heterodimers to control the growth and proliferation of breast cancer cells. However, the underlying cell signaling mechanism remained unclear. METHODS: To determine the effect of the interaction of the two systems in breast cancer, we employed triple-negative breast cancer cell lines MDA-MB-231 and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer, Stress, Anesthesia, and Immune Response
• Share to Neuropeptides and Animal Physiology
• Share to Wnt/β-catenin signaling in development and cancer