Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila.

Molecular biology of the cell - 1 May 2010

Fabian Lacramioara, Wei Ho-Chun, Rollins Janet, Noguchi Tatsuhiko, Blankenship J Todd, Bellamkonda Kishan, Polevoy Gordon, Gervais Louis, Guichet Antoine, Fuller Margaret T, Brill Julie A

Abstract excerpt

During spermiogenesis, Drosophila melanogaster spermatids coordinate their elongation in interconnected cysts that become highly polarized, with nuclei localizing to one end and sperm tail growth occurring at the other. Remarkably little is known about the signals that drive spermatid polarity and elongation. Here we identify phosphoinositides as critical regulators of these processes. Reduction of plasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Exocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Phosphatidylinositol Phosphates

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Spermatids

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 20237161
DOI: 10.1091/mbc.e09-07-0582
PMCID: PMC2861613

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila.PMID 20237161Read ↗

The class I PITP giotto is required for Drosophila cytokinesis.Semantic proximity Read ↗

The Drosophila phosphatidylinositol transfer protein encoded by vibrator is essential to maintain cleavage-furrow ingression in cytokinesis.Semantic proximity Read ↗

Spermatid Cyst Polarization in Drosophila Depends upon apkc and the CPEB Family Translational Regulator orb2Semantic proximity Read ↗

PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte.Semantic proximity Read ↗

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males.Semantic proximity Read ↗

GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.Semantic proximity Read ↗

What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis.Semantic proximity Read ↗

Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release.Semantic proximity Read ↗

The SEPT12 complex is required for the establishment of a functional sperm head-tail junction.Semantic proximity Read ↗

Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.Semantic proximity Read ↗

The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.