Article
Identification of leptin gene variants in school children with early onset obesity.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet - 1 Dec 2009
Kongmacheep Paleerath, Sirikulchayanonta Chutima, Tungtrongchitr Rungsunn, Hancharoen Kitiphong
Abstract excerpt
OBJECTIVE: To investigate leptin gene variations in Thai primary school children. MATERIAL AND METHOD: Direct DNA sequencing was performed following polymerase chain reaction (PCR) amplification of the leptin gene in 30 obese children aged 10-12 years old. RESULTS: A heterozygous variant 19 (G > A), located in the non-coding region of exon 1 was detected in 13 subjects (43.3%, A: 0.22). Only 2 subjects (6.7%, G:...
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