Article
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Koharudin Leonardus M I, Liu Hao, Di Maio Roberto, Kodali Ravindra B, Graham Steven H, Gronenborn Angela M
Abstract excerpt
Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) has been implicated in Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies. However, the molecular basis for UCH-L1s involvement in proteinacious fibril formation is still elusive, especially in regard to the pathogenicity of the I93M mutation. Here we show that modification of UCH-L1 by cyclopentenone prostaglandins causes unfolding...
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