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Article

Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.

Biochemical and biophysical research communications - 25 Apr 2003

Nishikawa Kaori, Li Hang, Kawamura Ryoichi, Osaka Hitoshi, Wang Yu-Lai, Hara Yoko, Hirokawa Takatsugu, Manago Yoshimasa, Amano Taiju, Noda Mami, Aoki Shunsuke, Wada Keiji

Abstract excerpt

Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is a neuron-specific ubiquitin recycling enzyme. A mutation at residue 93 and polymorphism at residue 18 within human UCH-L1 are linked to familial Parkinson's disease and a decreased Parkinson's disease risk, respectively. Thus, we constructed recombinant human UCH-L1 variants and examined their structure (using circular dichroism) and hydrolase activities. We...

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PMID: 12705903
DOI: 10.1016/s0006-291x(03)00555-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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