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Article

The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells

14 Apr 2008

Abstract excerpt

A number of studies have associated the S18Y polymorphic variant of UCH-L1 with protection from sporadic Parkinson's Disease (PD). The mechanism involved in this protective function is unknown, but has generally been assumed to be linked to the ubiquitin-proteasome system (UPS). In the current study, we have investigated the effects of overexpression of UCH-L1 and its variants, including S18Y, in neuronal cells....

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PMID: 18411255
DOI: 10.1093/hmg/ddn115

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