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Article

A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1.

Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2010

Neumann Christopher S, Walsh Christopher T, Kay Robert R

Abstract excerpt

Differentiation-inducing factor 1 (DIF-1) is a polyketide-derived morphogen which drives stalk cell formation in the developmental cycle of Dictyostelium discoideum. Previous experiments demonstrated that the biosynthetic pathway proceeds via dichlorination of the precursor molecule THPH, but the enzyme responsible for this transformation has eluded characterization. Our recent studies on prokaryotic...

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Identifiers

PMID: 20231486
DOI: 10.1073/pnas.1001681107
PMCID: PMC2851905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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