Article
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.
Nature chemical biology - 1 Sept 2006
Austin Michael B, Saito Tamao, Bowman Marianne E, Haydock Stephen, Kato Atsushi, Moore Bradley S, Kay Robert R, Noel Joseph P
Abstract excerpt
Differentiation-inducing factors (DIFs) are well known to modulate formation of distinct communal cell types from identical Dictyostelium discoideum amoebas, but DIF biosynthesis remains obscure. We report complimentary in vivo and in vitro experiments identifying one of two approximately 3,000-residue D. discoideum proteins, termed 'steely', as responsible for biosynthesis of the DIF acylphloroglucinol scaffold....
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