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Article

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 1995

Seung L P, Rowley D A, Dubey P, Schreiber H

Abstract excerpt

During tumor progression, variants may arise that grow more vigorously. The fate of such variants depends upon the balance between aggressiveness of the variant and the strength of the host immunity. Although enhancing host immunity to cancer is a logical objective, eliminating host factors necessary for aggressive growth of the variant should also be considered. The present study illustrates this concept in the...

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Identifiers

PMID: 7603979
DOI: 10.1073/pnas.92.14.6254
PMCID: PMC41496

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