Article
Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor.
Biochemical and biophysical research communications - 9 Apr 2010
Ise Nobuyuki, Omi Kazuya, Miwa Kyoko, Honda Hideo, Higashiyama Shigeki, Goishi Katsutoshi
Abstract excerpt
The precise regulation of epidermal growth factor receptor (EGFR) is crucial for its function in cellular growth control. Although many antibodies against EGFR have been developed and used to analyze its regulation and function, it is not yet easy to analyze activated EGFR specifically. Activated EGFR has been mainly detected by its phosphorylation state using anti-phospho-EGFR and anti-phosphotyrosine...
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