Article
Diseases of the human mitochondrial oxidative phosphorylation system.
Advances in experimental medicine and biology - 1 Jan 2009
Montoya Julio, López-Gallardo Ester, Herrero-Martín María Dolores, Martínez-Romero Iñigo, Gómez-Durán Aurora, Pacheu David, Carreras Magdalena, Díez-Sánchez Carmen, López-Pérez Manuel J, Ruiz-Pesini Eduardo
Abstract excerpt
Mitochondrial diseases, or diseases of the oxidative phosphorylation system, consist of a group of disorders originated by a deficient synthesis of ATP. This system is composed of proteins codified in the two genetic systems of the cell, the nuclear and the mitochondrial genomes, and, therefore, the mode of inheritance could be either mendelian or maternal. The diseases can also appear sporadically. Due to the...
Topics
- DNA, Mitochondrial
- Humans
- Mitochondria
- Mitochondrial Diseases
- Multifactorial Inheritance
- Mutation
- Oxidative Phosphorylation