Article
Mitochondrial diseases--an expanding spectrum of disorders and affected genes.
Experimental physiology - 1 Jan 2003
von Kleist-Retzow Jürgen-Christoph, Schauseil-Zipf Ulrike, Michalk Dietrich V, Kunz Wolfram S
Abstract excerpt
Mitochondrial diseases are a heterogeneous group of disorders caused by the impairment of the mitochondrial oxidative phosphorylation system which have been associated with various mutations of the mitochondrial DNA (mtDNA) and nuclear gene mutations. The clinical phenotypes are very diverse and the spectrum is still expanding. This review gives an overview of the principal clinical phenotypes and the molecular...
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