Article
Mitochondrial disorders.
Brain : a journal of neurology - 1 Oct 2004
Zeviani Massimo, Di Donato Stefano
Abstract excerpt
In the medical literature the term 'mitochondrial disorders' is to a large extent applied to the clinical syndromes associated with abnormalities of the common final pathway of mitochondrial energy metabolism, i.e. oxidative phosphorylation (OXPHOS). Faulty oxidative phosphorylation may be due to overall dysfunction of the respiratory chain, a heteromultimeric structure embedded in the inner mitochondrial...
Topics
- Adult
- Child
- DNA
- DNA, Mitochondrial
- Electron Transport
- Gene Rearrangement
- Humans
- Mitochondrial Diseases
- Mutation
- Oxidative Phosphorylation
- Point Mutation
- Proteins