Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease.

Journal of Crohn's & colitis - 1 Mar 2012

Girardin Marc, Dionne Serge, Goyette Philippe, Rioux John, Bitton Alain, Elimrani Ihsan, Charlebois Patrick, Qureshi Ijaz, Levy Emile, Seidman Ernest G

Abstract excerpt

BACKGROUND: The IBD5 locus is a genetic risk factor for IBD, particularly Crohn's Disease, coding for the organic cation/carnitine transporters (OCTN1 and 2). Two variants of OCTN are associated with susceptibility to Crohn's Disease. Modified transport of carnitine in vitro has been reported for a polymorphism of OCTN1. The aim was to investigate the function of intestinal OCTNs in IBD in relation to genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carnitine
Share to Colon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microvilli

Share to Organic Cation Transport Proteins

Share to Sodium

Share to Solute Carrier Family 22 Member 5

Share to Symporters

Source

Identifiers

PMID: 22325173
DOI: 10.1016/j.crohns.2011.08.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease.PMID 22325173Read ↗

A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn’s disease locus (IBD5)Semantic proximity Read ↗

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.Semantic proximity Read ↗

Association of the organic cation transporter OCTN genes with Crohn's disease in the Spanish population.Semantic proximity Read ↗

Functional variants of OCTN cation transporter genes are associated with Crohn disease.Semantic proximity Read ↗

Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD.Semantic proximity Read ↗

Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.Semantic proximity Read ↗

Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes.Semantic proximity Read ↗

Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.Semantic proximity Read ↗

Plasma carnitine ester profiles in Crohn's disease and ulcerative colitis patients with different IGR2230a_1 genotypes.Semantic proximity Read ↗

Increased ergothioneine tissue concentrations in carriers of the Crohn’s disease risk-associated 503F variant of the organic cation transporter OCTN1Semantic proximity Read ↗

Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.Semantic proximity Read ↗

Evidence for association of OCTN genes and IBD5 with ulcerative colitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.