Article
[Detection of multiple gene mutations in non-small-cell lung cancer by suspension microarray].
Zhonghua yi xue za zhi - 29 Dec 2009
Wang Dong, Ye Yu-kun, Su Chang-qing, Rong Tie-hua, Guo Ai-yong, Yi Jin-hua, Liu Yan-jun
Abstract excerpt
OBJECTIVE: To construct a high-throughput suspension microarray for detecting the hotspot gene mutations of p53, p16, retinoblastoma (Rb) and epidermal growth factor receptor (EGFR) and to investigate the significance of this multimarker panel in molecular diagnosis of non-small-cell lung cancer (NSCLC). METHODS: The specific probes of normal or mutated sequences targeting the hotspot mutation sites of p53, p16,...
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